2mg/Vial Triptorelin Acetate CAS 57773-63-4 Treating of Advanced Prostate Cancer

2mg/Vial Triptorelin Acetate CAS 57773-63-4 Treating of Advanced Prostate Cancer

Product Name Triptorelin Acetate
Sequence Glp-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
Cas No. 57773-63-4
Molecular Formula C64H82N18O13
Molecular Weight 1311.46
Purity (HPLC) 99.0% min.
Appearance White powder
Single Impurity (HPLC) 1.0%max
Amino Acid Composition ±10% of theoretical
Peptide Content (N%) ≥80.0%
Water Content(Karl Fischer) ≤6.0%
Acetate Content (HPIC) ≤15.0%
MS(ESI) Consistent
Mass Balance 95.0~105.0%
Specific Rotation (20/D) -65.0~-75.0°(c=0.5 1%HAc)

Description:

Treating symptoms of advanced prostate cancer. It may be used for other conditions as determined by your doctor. Triptorelin is a synthetic analogue of gonadotropin-releasing hormone (GnRH) agonist. It works by decreasing the production of certain hormones, which reduces testosterone levels in the body.

Using a hormone therapy regimen to treat the cancer is typically the first method of treatment doctors choose in the battle against prostate cancer. The other two options are surgery to remove the prostate and radiation therapy to try and kill the cancer cells. When using triptorelin as part of a cancer treatment, the drug can only be administered through injection directly into a muscle. Depending on individual circumstances, doctors will prescribe a regimen of injections over the course of every four, 12, or 24 weeks, with the average being every three to six months. In some cases, the doctor will give injections in the office, and in others, the doctor will teach the patient how to administer the injections.

Application:

Triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions, and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl and Diphereline and Gonapeptyl.

In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl.In India, Dr. Reddy's Laboratories has launched recently Triptorelin under the brand name "Pamorelin LA". During the treatment of prostate cancer it does cause a surge of testosterone, known as a flare effect. In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy.

NOTICE:

1.Triptorelin is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using triptorelin at home, a health care provider will teach you how to use it. Be sure you understand how to use triptorelin. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.Triptorelin is injected into the muscle.
Rotate the injection site. Do not inject into an area of skin that is red, hard, or bruised, or has scars or stretch marks.
Do not use triptorelin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use.

2.After taking triptorelin, the patient may experience some side effects. Common complaints are weakness, lack of energy, hot flashes, and upset stomach. More severe and long-term side effects can include anemia, a decrease in muscle mass, and osteoporosis. It should be noted that triptorelin doesn't cure prostate cancer; it's used to treat the symptoms of the disease and limit its progression. In cases where hormone therapy fails to stop the spread of the cancer cells, doctors will then consider the alternative treatments of chemotherapy and surgery.

How triptorelin works:

Hormones are substances produced naturally in the body. They act as chemical messengers and help control the activity of cells and organs.
Hormonal therapies interfere with the way hormones are made or how they work in the body.

Most prostate cancers need the hormone testosterone in order to grow. Almost all testosterone in men is made by the testicles. A very small amount is made by the adrenal glands, which sit above the kidneys. Triptorelin stops the testicles from making testosterone. This reduces testosterone levels and may shrink the prostate cancer or stop it growing.
 

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